雌激素与老年性耳聋的关系
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中华首席医学网 2007年12月13日 11:09:12 Thursday
作者:汪晓锋
作者单位:福建医科大学附属第一医院耳鼻咽喉
【摘要】 雌激素与老年性耳聋的关系正逐渐受到重视,但其发病机制尚不很清楚,本文主要综述雌激素对神经元的保护作用及其与老年性耳聋的相关性,探讨雌激素减少可能介导的老年性耳聋的发病机制。
【关键词】 老年 聋 雌激素
【参考文献】
[1] 〖ZK(#]Gates G A, Mills J H. Presbycusis[J]. Lancet, 2005, 366(9491):11111120.
[2] Spicer S S, Schulte B A. Pathologic changes of presbycusis begin in secondary processes and spread to primary processes of strial marginal cells[J]. Hear Res, 2005, 205(12):225240.
[3] Ichimiya I, Suzuki M, Mogi G. Agerelated changes in the murine cochlear lateral wall[J]. Hear Res, 2000, 139:116122.
[4] Yamasoba T, Someya S, Yamada C, et al. Role of mitochondrial dysfunction and mitochondrial DNA mutations in agerelated hearing loss[J]. Hear Res, 2006, 226:185193.
[5] Stenberg A E, Wang H, Fish J 3rd, et al. Estrogen receptors in the normal adult and developing human inner ear and in Turner′s syndrome[J]. Hear Res, 2001, 157:8792.
[6] Stenberg A E, Simonoska R, Stygar D, et al. Effect of estrogen and antiestrogens on the estrogen receptor content in the cochlea of ovariectomized rats[J]. Hear Res, 2003, 182:1923.
[7] Sohrabji F, Miranda R, ToranAllerand C D. Identifcation of a putative estrogen response element in the gene encoding brainderived neurotrophic factor[J]. Proc NatlAcadSci USA, 1995, 92:1111011114.
[8] Dong L, Wang W, Wang F, et al. Mechanisms of transcriptional activation of bcl2 gene expression by 17betaestradiol in breast cancer cells[J].J Biol Chem, 1999, 274:3209932107.
[9] GarciaSegura L M, CardonaGomez P, Naftolin F, et al. Estradiol upregulates bcl2 expression in adult brain neurons[J].Neuroreport,1998,9:595597.
[10] 〖ZK(#]Merry D E, Korsmeyer S J. Bcl2 gene family in the nervous system[J]. Ann Rev Neurosci, 1997, 20:245267.
[11] Pike C J. Estrogen modulates neuronal BclxL expression and betaamyloidinduced apoptosis: relevance to Alzheimer′s disease[J]. J Neurochem, 1999,72:15521563.
[12] Hill R A, Pompolo S, Jones M E, et al. Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice[J]. Mol Cell Neurosci, 2004, 27:466476.
[13] Weaver C E Jr, ParkChung M, Gibbs T T, et al. 17betaEstradiol protects against NMDAinduced excitotoxicity by direct inhibition of NMDA receptors[J]. Brain Res, 1997, 761:338341.
[14] Brooke S, Chan R, Howard S, et al. Endocrine modulation of the neurotoxicity of gp120: implications for AIDSrelated dementia complex[J]. Proc Natl Acad Sci U S A, 1997, 94:94579462.
[15] Pirvola U, Ylikoski J. Neurotrophic factors during inner ear development[J]. Curr Top Dev Biol, 2003, 57:207223.
[16] ToranAllerand C D. The estrogen/neurotrophin connection during neural development: is colocalization of estrogen receptors with the neurotrophins and their receptors biologically relevant[J]. Dev Neurosci, 1996,18:3648.
[17] Ji L, Mochon E, Arcinas M, et al. CREB proteins function as positive regulators of the translocated bcl2 allele in t(14;18) lymphomas[J]. J Biol Chem, 1996, 271:2268722691.
[18] Vossler M R, Yao H, York R D, et al. cAMP activates MAP kinase and Elk1 through a BRaf and Rap1dependent pathway[J]. Cell, 1997,89:7382.
[19] Zhang Y, Yao B, Delikat S, et al. Kinase suppressor of Ras is ceramideactivated protein kinase[J]. Cell, 1997, 89:6372.
[20] Zheng J, Ramirez V D. Rapid inhibition of rat brain mitochondrial proton F0F1ATPase activity by estrogens: comparison with Na+, K+ ATPase of porcine cortex[J]. Eur J Pharmacol, 1999, 368:95102.
[21] Kim S H, Kang B M, Chae H D, et al. The association between serum estradiol level and hearing sensitivity in postmenopausal women[J]. Obstet Gynecol Obstetrics Gynecol, 2002, 99:726730.
[22] Guimaraes P, Zhu X, Cannon T, et al. Sex differences in distortion product otoacoustic emissions as a function of age in CBA mice[J]. Hear Res, 2004,192:8389.
[23] Lurie S N, Doraiswamy P M, Husain M M, et al. In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age[J]. J Clin Endocrinol Metab, 1990,71:505508.
[24] Prazma J, Carrasco V N, Butler B, et al. Cochlear microcirculation in young and old gerbils[J]. Arch Otolaryngol Head Neck Surg, 1990, 116:932636.
[25] 戴德.氧自由基与氨基糖苷类抗生素致听觉损害的相关性研究[J]. 现代预防医学, 2005, 32:427429.
[26] Wei Y H, Lu C Y, Lee H C, et al. Oxidative damage and mutation to mitochondrial DNA and agedependent decline of mitochondrial respiratory function[J]. Ann N Y Acad Sci, 1998, 854:155170.
[27] de Rivera C, ShukittHale B, Joseph J A, et al. The effects of antioxidants in the senescent auditory cortex[J]. Neurobiol Aging, 2006, 27:10351044.
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