Fc RI -ITAM Is Differentially Required for Mast Cell Function In Vivo

中华首席医学网    2008年06月26日 22:18:33 Thursday  

 

作者：Daiju Sakurai,,, Sho Yamasaki,, Kanako Arase,, Seung Yong Park,, Hisashi Arase,, Akiyoshi Konno, and Takashi Saito,,

作者单位：Departments of Molecular Genetics and Otorhinolaryngology, Graduate School of Medicine, Chiba University, Chiba, Japan; PRESTO, Japan Science and Technology, Kawaguchi, Japan; and Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan

《免疫学杂志》2004年2月173卷2期 文章精华

 

【摘要】  The cross-linking of IgE-bound Fc RI by Ags triggers mast cell activation leading to allergic reactions. The in vivo contribution of Fc RI signaling to IgE/Fc RI-mediated mast cell responses has not yet been elucidated. In this study Fc RI -/- mast cells were reconstituted with either wild-type or mutant Fc RI in transgenic mice and transfected mast cells in vitro. We demonstrate that Fc RI -immunoreceptor tyrosine-based activation motif is essential for degranulation, cytokine production, and PG synthesis as well as for passive systemic anaphylaxis. Recent reports have suggested that cell surface Fc RI expression and mast cell survival are regulated by IgE in the absence of Ag, although the molecular mechanism is largely unknown. We also found that the promotion of mast cell survival by IgE without Ags is mediated by signals through the Fc RI -immunoreceptor tyrosine-based activation motif. In contrast, the IgE-mediated up-regulation of Fc RI is independent of Fc RI signaling. These results indicate that Fc RI -mediated signals differentially regulate the receptor expression, activation, and survival of mast cells and systemic anaphylaxis.

【关键词】  Differentially Required Function

【参考文献】
  Kinet, J. P.. 1999. The high-affinity IgE receptor (Fc RI): from physiology to pathology. Annu. Rev. Immunol. 17 : 931.

Turner, H., J. P. Kinet. 1999. Signalling through the high-affinity IgE receptor Fc RI. Nature 402 : B24.

Yamaguchi, M., C. S. Lantz, H. C. Oettgen, I. M. Katona, T. Fleming, I. Miyajima, J. P. Kinet, S. J. Galli. 1997. IgE enhances mouse mast cell Fc RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J. Exp. Med. 185 : 663.

Asai, K., J. Kitaura, Y. Kawakami, N. Yamagata, M. Tsai, D. P. Carbone, F. T. Liu, S. J. Galli, T. Kawakami. 2001. Regulation of mast cell survival by IgE. Immunity 14 : 791.

Kalesnikoff, J., M. Huber, V. Lam, J. E. Damen, J. Zhang, R. P. Siraganian, G. Krystal. 2001. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 14 : 801.

Ra, C., M. H. Jouvin, J. P. Kinet. 1989. Complete structure of the mouse mast cell receptor for IgE (Fc RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J. Biol. Chem. 264 : 15323.

Reth, M.. 1989. Antigen receptor tail clue. Nature 338 : 383.

Parravicini, V., M. Gadina, M. Kovarova, S. Odom, C. Gonzalez-Espinosa, Y. Furumoto, S. Saitoh, L. E. Samelson, J. J. OShea, J. Rivera. 2002. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat. Immunol. 3 : 741.

Lin, S., C. Cicala, A. M. Scharenberg, J. P. Kinet. 1996. The Fc RI subunit functions as an amplifier of Fc RI -mediated cell activation signals. Cell 85 : 985.

Dombrowicz, D., S. Lin, V. Flamand, A. T. Brini, B. H. Koller, J. P. Kinet. 1998. Allergy-associated FcR is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity 8 : 517.

Kihara, H., R. P. Siraganian. 1994. Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. J. Biol. Chem. 269 : 22427.

Jouvin, M. H., M. Adamczewski, R. Numerof, O. Letourneur, A. Valle, J. P. Kinet. 1994. Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor. J. Biol. Chem. 269 : 5918.

Daeron, M.. 1997. Fc receptor biology. Annu. Rev. Immunol. 15 : 203.

Park, S. Y., S. Ueda, H. Ohno, Y. Hamano, M. Tanaka, T. Shiratori, T. Yamazaki, H. Arase, N. Arase, A. Karasawa, et al 1998. Resistance of Fc receptor-deficient mice to fatal glomerulonephritis. J. Clin. Invest. 102 : 1229.

Takai, T., M. Li, D. Sylvestre, R. Clynes, J. V. Ravetch. 1994. FcR chain deletion results in pleiotrophic effector cell defects. Cell 76 : 519.

Sylvestre, D. L., J. V. Ravetch. 1994. Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science 265 : 1095.

Clynes, R., C. Dumitru, J. V. Ravetch. 1998. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 279 : 1052.

Watanabe, N., B. Akikusa, S. Y. Park, H. Ohno, L. Fossati, G. Vecchietti, J. E. Gessner, R. E. Schmidt, J. S. Verbeek, B. Ryffel, et al 1999. Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggering Fc receptors. Blood 94 : 3855.

Ravetch, J. V., S. Bolland. 2001. IgG Fc receptors. Annu. Rev. Immunol. 19 : 275.

Takai, T.. 2002. Roles of Fc receptors in autoimmunity. Nat. Rev. Immunol. 2 : 580.

Matsumoto, K., N. Watanabe, B. Akikusa, K. Kurasawa, R. Matsumura, Y. Saito, I. Iwamoto, T. Saito. 2003. Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. Arthritis Rheum. 48 : 486.

Nishi, M., Y. Ishida, T. Honjo. 1988. Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice. Nature 331 : 267.

Liu, F. T., J. W. Bohn, E. L. Ferry, H. Yamamoto, C. A. Molinaro, L. A. Sherman, N. R. Klinman, D. H. Katz. 1980. Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization. J. Immunol. 124 : 2728.

Rivera, J., J. P. Kinet, J. Kim, C. Pucillo, H. Metzger. 1988. Studies with a monoclonal antibody to the subunit of the receptor with high affinity for immunoglobulin E. Mol. Immunol. 25 : 647.

Tohyama, N., H. Karasuyama, T. Tada. 1990. Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA. J. Exp. Med. 171 : 389.

Chen, X. J., N. Lycke, L. Enerback. 1999. Surface and gene expression of immunoglobulin E receptors on mast cells and mast cell numbers in interleukin-4-gene knockout mice. Immunology 96 : 544.

Ono, S., H. Ohno, T. Saito. 1995. Rapid turnover of the CD3 chain independent of the TCR-CD3 complex in normal T cells. Immunity 2 : 639.

Scharenberg, A. M., S. Lin, B. Cuenod, H. Yamamura, J. P. Kinet. 1995. Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering. EMBO J. 14 : 3385.

Dombrowicz, D., V. Flamand, K. K. Brigman, B. H. Koller, J. P. Kinet. 1993. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor chain gene. Cell 75 : 969.

Hiraoka, S., Y. Furumoto, H. Koseki, Y. Takagaki, M. Taniguchi, K. Okumura, C. Ra. 1999. Fc receptor subunit is required for full activation of mast cells through Fc receptor engagement. Int. Immunol. 11 : 199.

Ryan, J. J., C. A. Kinzer, W. E. Paul. 1995. Mast cells lacking the high affinity immunoglobulin E receptor are deficient in Fc RI messenger RNA. J. Exp. Med. 182 : 567.

Matsuda, H., N. Watanabe, G. P. Geba, J. Sperl, M. Tsudzuki, J. Hiroi, M. Matsumoto, H. Ushio, S. Saito, P. W. Askenase, et al 1997. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int. Immunol. 9 : 461.

Morita, E., S. Kaneko, T. Hiragun, H. Shindo, T. Tanaka, T. Furukawa, A. Nobukiyo, S. Yamamoto. 1999. Fur mites induce dermatitis associated with IgE hyperproduction in an inbred strain of mice, NC/Kuj. J. Dermatol. Sci. 19 : 37.

Letourneur, F., R. D. Klausner. 1991. T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor family proteins. Proc. Natl. Acad. Sci. USA 88 : 8905.

Paolini, R., V. Renard, E. Vivier, K. Ochiai, M. H. Jouvin, B. Malissen, J. P. Kinet. 1995. Different roles for the Fc RI chain as a function of the receptor context. J. Exp. Med. 181 : 247.

Borkowski, T. A., M. H. Jouvin, S. Y. Lin, J. P. Kinet. 2001. Minimal requirements for IgE-mediated regulation of surface Fc RI. J. Immunol. 167 : 1290.

Kubo, S., K. Matsuoka, C. Taya, F. Kitamura, T. Takai, H. Yonekawa, H. Karasuyama. 2001. Drastic up-regulation of Fc RI on mast cells is induced by IgE binding through stabilization and accumulation of Fc RI on the cell surface. J. Immunol. 167 : 3427.

Kawakami, Y., J. Kitaura, A. B. Satterthwaite, R. M. Kato, K. Asai, S. E. Hartman, M. Maeda-Yamamoto, C. A. Lowell, D. J. Rawlings, O. N. Witte, et al 2000. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J. Immunol. 165 : 1210.

Kawakami, T., S. J. Galli. 2002. Regulation of mast cell and basophil function and survival by IgE. Nat. Rev. Immunol. 2 : 773.

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